Medical Terms
Note:
This website is not intended as a substitute for professional medical advice and does not address specific treatments or conditions specific to any patient. All health and treatment decisions must be made in consultation with your physician(s), utilizing your specific medical information. The information on this website is subject to change.
The information provided below has been modified from that furnished by the National Institutes of Health and the National Cancer Institute of the United States of America.
WHAT IS HODGKIN’S DISEASE?
Hodgkin’s disease is a type of lymphoma. Lymphomas are cancers that develop in the lymphatic system, a part of the body’s immune system. The job of the lymphatic system is to help fight diseases and infection.
The lymphatic system includes a network of thin tubes that branch, like blood vessels, into the tissues throughout the body. Lymphatic vessels carry lymph, a colorless, watery fluid that contains infection-fighting cells called lymphocytes. Along this network of vessels are groups of small, bean-shaped organs called lymph nodes that filter the lymph as it passes through the nodes. Clusters of lymph nodes are found in the underarm, groin, neck, and abdomen. Other parts of the lymphatic system are the spleen, thymus, tonsils, and bone marrow.
Like all types of cancer, Hodgkin’s disease affects the body’s cells. Healthy cells grow, divide, and replace themselves in an orderly manner. This process keeps the body in good repair. In Hodgkin’s disease, cells in the lymphatic system grow abnormally and can spread to other organs. As the disease progresses, the body is less able to fight infection.
Hodgkin’s disease is rare. It accounts for less than 1 percent of all cases of cancer in this country. It is most often seen in young people aged 15 to 34 and in people over the age of 55. Other cancers of the lymphatic system are called non-Hodgkin’s lymphomas.
WHAT ARE SYMPTOMS OF HODGKIN’S DISEASE?
The most common symptom of Hodgkin’s disease is a painless swelling in the lymph nodes in the neck, underarm, or groin. Other symptoms may include fevers, night sweats, tiredness, weight loss, or itching skin. However, these symptoms are not sure signs of cancer. They may also be caused by many common illnesses, such as the flu or other infections. But it is important to see a doctor if any of these symptoms lasts longer than 2 weeks. Any illness should be diagnosed and treated as early as possible, and this is especially true of Hodgkin’s disease.
HOW IS HODGKIN’S DISEASE DIAGNOSED?
If Hodgkin’s disease is suspected, the doctor will ask about the patient’s medical history and will perform a thorough physical exam. Blood tests and x-rays of the chest, bones, liver, and spleen will also be done.
Tissue from an enlarged lymph node will be removed. This is known as a biopsy and is the only sure way to tell if cancer is present. A pathologist will look at the tissue under the microscope for Reed-Sternberg cells, abnormal cells that are usually found with Hodgkin’s disease. When Hodgkin’s disease is diagnosed, the doctor needs to know the stage, or extent, of the disease. Knowing the stage is very important for planning treatment. The stage indicates where the disease has spread and how much tissue is affected. In staging, the following are checked:
1. The number and location of affected lymph nodes
2. Whether the affected lymph nodes are above, below, or on both sides of the diaphragm (the thin muscle under the lungs and heart that separates the chest from the abdomen)
3. Whether the disease has spread to the bone marrow, to the spleen, or to places outside the lymphatic system, such as the liver
In staging, the doctor usually order several tests, including biopsies of the lymph nodes, liver, and bone marrow. Many patients have lymphangiograms, x-rays of the lymphatic system using a special dye to outline the lymph nodes and vessels. Another test is computed tomography (also called CT or CAT scan), a series of x-rays of cross-sections of the body.
HOW IS HODGKIN’S DISEASE TREATED?
Treatment for Hodgkin’s disease usually includes radiation therapy or chemotherapy. Sometimes, both are given. Treatment decisions depend on the stage of disease, its location in the body, which symptoms are present, and the general health and age of the patient (treatment for children with Hodgkin’s disease is more complex and is not discussed here).
Often, patients are referred to doctors or medical centers that specialize in the different treatments of Hodgkin’s disease. Also, patients may want to talk with their doctor about taking part in a research study of new treatment methods.
Radiation therapy uses high-energy rays to damage cancer cells and stop their growth. Radiation therapy is generally given in a hospital or clinic. Most often, patients receive radiation therapy 5 days a week for several weeks as outpatients.
Chemotherapy is the use of drugs to kill cancer cells. To treat Hodgkin’s disease, the doctor prescribes a combination of drugs that work together. The drugs may be given in different ways: Some are given by mouth; others are injected into an artery, vein, or muscle. The drugs travel through the bloodstream to almost every part of the body. Chemotherapy is usually given in cycles: a treatment period followed by a rest period, then another treatment period, and so on.
WHAT ARE THE SIDE EFFECTS OF TREATMENT FOR HODGKIN’S DISEASE?
The methods used to treat Hodgkin’s disease are very powerful. That is why the treatment often causes side effects – both short-term and permanent. Side effects depend on the type of treatment and on the part of the body being treated. Also, each patient may respond differently.
During radiation therapy, patients can become unusually tired as therapy continues. Resting as much as possible is important. Skin reactions (redness or dryness) in the area being treated are common. Patients should be gentle with the treated area of skin. Lotions and creams should not be used without the doctor’s advice. When the chest is treated, patients can have a dry, sore throat and have trouble swallowing. Sometimes they have shortness of breath or a dry cough. Radiation treatment to the lower abdomen can cause nausea, vomiting, or diarrhea. Some patients have tingling or numbness in their arms, legs, and lower back. These side effects gradually disappear when treatment is over.
The side effects of chemotherapy depend mainly on the drugs that are given. In general, anticancer drugs affect rapidly growing cells, such as blood cells that fight infection, cells that line the digestive tract, and cells in the hair follicles. As a result, patients can have side effects such as a lowered resistance to infection, nausea, vomiting, or mouth sores. They can also have less energy and may their hair.
Loss of appetite can be a problem for patients receiving radiation therapy or chemotherapy. Researchers are learning that patients who eat well may be better able to tolerate the side effects of their treatment. Therefore, nutrition is an important part of the treatment plan. Eating well means getting enough calories to prevent weight loss and having enough protein in the diet to build and repair skin, hair, muscles, and organs. Many patients find that eating several small meals and snacks throughout the day is easier than trying to have three large meals.
Treatment for Hodgkin’s disease can cause fertility problems. Women’s menstrual periods may stop. Periods are more likely to return in younger women. In men, both Hodgkin’s disease and its treatment can affect fertility. Younger men are more likely to regain their fertility. Sperm banking before treatment can be an option for some men.
The side effects that patients have during cancer therapy vary from person to person and may even be different from one treatment to the next. Attempts are made to plan treatment to keep problems to a minimum. Doctors, nurses, and dietitians can explain the side effects of cancer treatment and can suggest ways to deal with them.
WHAT HAPPENS AFTER TREATMENT FOR HODGKIN’S DISEASE?
Regular follow-up exams are very important for anyone who has been treated for Hodgkin’s disease. The doctor will want to continue to watch the patient closely for several years. Generally, checkups include a thorough physical exam, x-rays, blood tests, and other laboratory tests.
Patients treated for Hodgkin’s disease have an increased risk of developing other types of cancer later in life, especially leukemia. Patients should follow their doctor’s recommendations on health care and checkups. Having regular checkups allows problems to be detected and treated promptly if they should arise.
When people have cancer, life can change for them and for the people who care about them. These changes in daily life can be difficult to handle. It is natural for a person with Hodgkin’s disease to have many different and sometimes confusing emotions.
At times, patients and family members may be depressed, angry, or frightened. At other times, feelings may vary from hope to despair or from courage to fear. Patients usually are better able to cope with their emotions if they can talk openly about their illness and their feelings with family members and friends.
Concerns about the future, as well as about medical tests, treatments, a hospital stay, and medical bills, are common. Talking to doctors, nurses, or other members of the health care team can help to ease fear and confusion. Patients can take an active part in decisions about their medical care by asking questions about their treatment. Patients and family members often find it helpful to write down questions for the doctor as they think of them. Taking notes during visits to the doctor can help them remember what was said. Patients should ask the doctor to explain anything that is not clear.
Patients have many important questions to ask about their disease, and their doctor is the best person to provide answers. Most people want to learn how Hodgkin’s disease can be treated, how successful the treatment is likely to be, and how much the treatment is expected to cost.
The patient’s doctor is the best person to give advice about working or limiting other activities, but it may be hard for some people to talk to the doctor about their feelings and other very personal matters. Many patients find it helpful to talk with others who are facing similar problems. This kind of help is available through cancer-related support groups. It also may be helpful to talk with a nurse, social worker, counselor, or member of the clergy.
WHAT DOES THE FUTURE HOLD FOR PATIENTS WITH HODGKIN’S DISEASE?
More than 8 million Americans living today have had some type of cancer. Thirty years ago, few patients with Hodgkin’s disease recovered from their illness. Now, because of modern radiation therapy and combination chemotherapy, more than 75 percent of all newly diagnosed Hodgkin’s disease patients are curable. The chances for recovery continue to improve as scientists find new and more effective treatments.
Doctors often talk about “surviving” cancer, or they may use the word “remission” rather than “cure.” Even though many patients recover completely, doctors use these terms because Hodgkin’s disease can recur. Patients are naturally concerned about their future and may try to use statistics they have read or heard about to try to figure out their own chances of being cured. It is important to remember, however, that statistics are averages based on the experiences of large numbers of people, and no two cancer patients are alike. Only the doctor who takes care of a patient knows enough about that person to discuss the prognosis.
Scientists at hospitals and medical centers all across the country are studying Hodgkin’s disease. They are trying to learn more about the possible causes of the disease and how it might be prevented.
In addition, scientists are exploring new methods of treatment, including new drugs, drug combinations, and combinations of radiation therapy and chemotherapy. Other methods, such as bone marrow transplantation and biological therapy, are being studied with some Hodgkin’s disease patients in clinical trials. These trials are designed to answer scientific questions and to find out whether a promising new treatment is both safe and effective. Patients who take part in clinical trials make an important contribution to medical science and may have the first chance to benefit from improved treatment methods.
HODGKINS DISEASE AT A GLANCE
* Hodgkin’s disease is a type of lymphoma (cancer of the lymphatic system)
* The most common symptom of Hodgkin’s disease is a painless swelling in the lymph nodes in the neck, underarm or groin
* Hodgkin’s disease is diagnosed when abnormal tissue is detected by a pathologist after a biopsy of an enlarged lymph node
* Treatment of Hodgkin’s disease depends on the symptoms, stage and location of disease, as well as the age and health of the patient
* Treatment of Hodgkin’s disease usually includes radiation therapy or chemotherapy
* Regular follow-up examinations are important after treatment for Hodgkin’s disease. Patients treated for Hodgkin’s disease have an increased risk of developing other types of cancer later in life, especially leukemia
Note:
This website is not intended as a substitute for professional medical advice and does not address specific treatments or conditions specific to any patient. All health and treatment decisions must be made in consultation with your physician(s), utilizing your specific medical information. The information on this website is subject to change.
WHAT IS THE BRAIN?
Together, the brain and spinal cord form the central nervous system. This complex system is part of everything we do. It controls the things we choose to do,like walk and talk,and the things our body does automatically,like breathe and digest food. The central nervous system is also involved with our senses; seeing, hearing, touching, tasting, and smelling, as well as our emotions, thoughts, and memory.
The brain is a soft, spongy mass of nerve cells and supportive tissue. It has three major parts: the cerebrum, the cerebellum, and the brain stem. The parts work together, but each has special functions.
The cerebrum, the largest part of the brain, fills most of the upper skull. It has two halves called the left and right cerebral hemispheres. The cerebrum uses information from our senses to tell us what is going on around us and tells our body how to respond. The right hemisphere controls the muscles on the left side of the body, and the left hemisphere controls the muscles on the right side of the body. This part of the brain also controls speech and emotions as well as reading, thinking, and learning.
The cerebellum, under the cerebrum at the back of the brain, controls balance and complex actions like walking and talking.
The brain stem connects the brain with the spinal cord. It controls hunger and thirst and some of the most basic body function, such as body temperature, blood pressure, and breathing.
The brain is protected by the bones of the skull and by a covering of three thin membranes called meninges. The brain is also cushioned and protected by cerebrospinal fluid. This watery fluid is produced by special cells in the four hollow spaces in the brain, called ventricles. It flows through the ventricles and in spaces between the meninges. Cerebrospinal fluid also brings nutrients from the blood to the brain and removes waste products from the brain.
The spinal cord is made up of bundles of nerve fibers. It runs down from the brain through a canal in the center of the bones of the spine. These bones protect the spinal cord. Like the brain, the spinal cord is covered by the meninges and cushioned by brospinal fluid.
Spinal nerves connect the brain with the nerves in most parts of the body. Other nerves go directly from the brain to the eyes, ears, and other parts of the head. This network of nerves carries messages back and forth between the brain and the rest of the body.
WHAT ARE BRAIN TUMORS?
The body is made up of many types of cells. Each type of cell has special functions. Most cells in the body grow and then divide in an orderly way to form new cells as they are needed to keep the body healthy and working properly. When cells lose the ability to control their growth, they divide too often and without any order. The extra cells form a mass of tissue called a tumor. Each year, more than 16,000 people find out they have a brain tumor. Tumors are benign or malignant.
Benign brain tumors do not contain cancer cells. Usually these tumors can be removed, and they are not likely to recur. Benign brain tumors have clear borders. Although they do not invade nearby tissue, they can press on sensitive areas of the brain and cause symptoms.
Malignant brain tumors contain cancer cells. They interfere with vital functions and are life-threatening. Malignant brain tumors are likely to grow rapidly and crowd or invade the tissue around them. Like a plant, these tumors may put out “roots” that grow into healthy brain tissue. If a malignant tumor remains compact and does not have roots, it is said to be encapsulated. When an otherwise benign tumor is located in a vital area of the brain and interferes with vital functions, it may be considered malignant (even though it contains no cancer cells).
Doctors refer to some brain tumors by grade – from low grade (grade I) to high grade (grade IV). The grade of a tumor refers to the way the cells look under a microscope. Cells from higher grade tumors are more abnormal looking and generally grow faster than cells from lower grade tumors; higher grade tumors are more malignant than lower grade tumors.
WHAT CAUSES BRAIN TUMORS?
The causes of brain tumors are not known. Researchers are trying to solve this problem. The more they can find out about the causes of brain tumors, the better the chances of finding ways to prevent them.
Doctors cannot explain why one person gets a brain tumor and another doesn’t, but they do know that no one can “catch” a brain tumor from another person. Brain tumors are not contagious
Although brain tumors can occur at any age, studies show that they are most common in two age groups. The first group is children 3 to 12 years old; the second is adults 40 to 70 years old.
By studying large numbers of patients, researchers have found certain risk factors that increase a person’s chance of developing a brain tumor. People with these risk factors have a higher-than-average risk of getting a brain tumor. For example, studies show that some types of brain tumors are more frequent among workers in certain industries, such as oil refining, rubber manufacturing, and drug manufacturing.
Other studies have shown that chemists and embalmers have a higher incidence of brain tumors. Researchers also are looking at exposure to viruses as a possible cause. Because brain tumors sometimes occur in several members of the same family, researchers are studying families with a history of brain tumors to see whether heredity is a cause. At this time, scientists do not believe that head injuries cause brain tumors to develop.
In most cases, patients with a brain tumor have no clear risk factors. The disease is probably the result of several factors acting together.
WHAT ARE PRIMARY BRAIN TUMORS?
Tumors that begin in the brain tissue are known as primary brain tumors. Secondary tumors are those that develop when cancer spreads to the brain. Primary brain tumors are classified by the type of tissue in which they begin. The most common brain tumors are gliomas, which begin in the glial (supportive) tissue. There are several types of gliomas:
* Astrocytomas arise from small, star-shaped cells called astrocytes. They may grow anywhere in the brain or spinal cord. In adults, astrocytomas most often arise in the cerebrum. In children, they occur in the brain stem, the cerebrum, and the cerebellum. A grade III astrocytoma is sometimes called anaplastic astrocytoma. A grade IV astrocytoma is usually called glioblastoma multiforme.
* Brain stem gliomas occur in the lowest, stemlike part of the brain. The brain stem controls many vital functions. Tumors in this area generally cannot be removed. Most brain stem gliomas are high-grade astrocytomas.
* Ependymomas usually develop in the lining of the ventricles. They also may occur in the spinal cord. Although these tumors can develop at any age, they are most common in childhood and adolescence.
* Oligodendrogliomas arise in the cells that produce myelin, the fatty covering that protects nerves. These tumors usually arise in the cerebrum. They grow slowly and usually do not spread into surrounding brain tissue. Oligodendrogliomas are rare. They occur most often in middle- aged adults but have been found in people of all ages.
There are other types of brain tumors that do not begin in glial tissue. Some of the most common are described below:
* Medulloblastomas were once thought to develop from glial cells. However, recent research suggests that these tumors develop from primitive (developing) nerve cells that normally do not remain in the body after birth. For this reason, medulloblastomas are sometimes called primitive neuroectodermal tumors (PNET). Most medulloblastomas arise in the cerebellum; however, they may occur in other areas as well. These tumors occur most often in children and are more common in boys than in girls.
* Meningiomas grow from the meninges. They are usually benign. Because these tumors grow very slowly, the brain may be able to adjust to their presence; meningiomas often grow quite large before they cause symptoms. They occur most often in women between 30 and 50 years of age.
* Schwannomas are benign tumors that begin in Schwann cells, which produce the myelin that protects the acoustic nerve, the nerve of hearing. Acoustic neuromas are a type of schwannoma. They occur mainly in adults. These tumors affect women twice as often as men.
* Craniopharyngiomas develop in the region of the pituitary gland near the hypothalamus. They are usually benign; however, they are sometimes considered malignant because they can press on or damage the hypothalamus and affect vital functions. These tumors occur most often in children and adolescents.
* Germ cell tumors arise from primitive (developing) sex cells, or germ cells. The most frequent type of germ cell tumor in the brain is the germinoma.
* Pineal region tumors occur in or around the pineal gland, a tiny organ near the center of the brain. The tumor can be slow growing (pineocytoma) or fast growing (pineoblastoma). The pineal region is very difficult to reach, and these tumors often cannot be removed
WHAT ARE SECONDARY BRAIN TUMORS?
Metastasis is the spread of cancer. Cancer that begins in other parts of the body may spread to the brain and cause secondary tumors. These tumors are not the same as primary brain tumors. Cancer that spreads to the brain is the same disease and has the same name as the original (primary) cancer. For example, if lung cancer spreads to the brain, the disease is called metastatic lung cancer because the cells in the secondary tumor resemble abnormal lung cells, not abnormal brain cells.
Treatment for secondary brain tumors depends on where the cancer started and the extent of the spread, as well as other factors, including the patient’s age, general health, and response to previous treatment.
WHAT ARE SYMPTOMS OF BRAIN TUMORS?
The symptoms of brain tumors depend mainly on their size and their location in the brain. Symptoms are caused by damage to vital tissue and by pressure on the brain as the tumor grows within the limited space in the skull. They also may be caused by swelling and a buildup of fluid around the tumor, a condition called edema . Symptoms also may be due to hydrocephalus , which occurs when the tumor blocks the flow of cerebrospinal fluid and causes it to build up in the ventricles. If a brain tumor grows very slowly, its symptoms may appear so gradually that they are overlooked for a long time.
The most frequent symptoms of brain tumors include:
* Headaches that tend to be worse in the morning and ease during the day
* Seizures (convulsions)
* Nausea or vomiting
* Weakness or loss of feeling in the arms or legs
* Stumbling or lack of coordination in walking (ataxic gait)
* Abnormal eye movements or changes in vision
* Drowsiness
* Changes in personality or memory
* Changes in speech
These symptoms may be caused by brain tumors or by other problems. If an individual is experiencing symptoms, they should consult a doctor right away.
HOW ARE BRAIN TUMORS DIAGNOSED?
To find the cause of a person’s symptoms, the doctor asks about the patient’s personal and family medical history and does a complete physical examination. In addition to checking general signs of health, the doctor does a neurologic exam. This includes checks for alertness, muscle strength, coordination, reflexes, and response to pain. The doctor also examines the eyes to check for swelling caused by a tumor pressing on the nerve that connects the eye and the brain.
Depending on the results of the physical and neurologic examinations, the doctor may request one or both of the following:
* A CT (or CAT) scan is a series of detailed pictures of the brain. The pictures are created by a computer linked to an x-ray machine. In some cases, a special dye is injected into a vein before the scan. The dye helps to show differences in the tissues of the brain
* MRI ( magnetic resonance imaging ) gives pictures of the brain, using a powerful magnet linked to a computer. MRI is especially useful in diagnosing brain tumors because it can “see” through the bones of the skull to the tissue underneath. A special dye may be used to enhance the likelihood of detecting a brain tumor
The doctor also may request other tests:
* A skull x-ray can show changes in the bones of the skull caused by a tumor. It can also show calcium deposits, which are present in some types of brain tumors
* In a brain scan, areas of abnormal growth in the brain are revealed and recorded on special film. A small amount of a radioactive material is injected into a vein. This dye is absorbed by the tumor, and the growth shows up on the film (the radiation leaves the body within 6 hours and is not dangerous)
* An angiogram, or arteriogram, is a series of x-rays taken after a special dye is injected into an artery (usually in the area where the abdomen joins the top of the leg). The dye, which flows through the blood vessels of the brain, can be seen on the x-rays. These x-rays can show the tumor and the blood vessels that lead to it
* A myelogram is an x-ray of the spine. A special dye is injected into the cerebrospinal fluid in the spine, and the patient is tilted to allow the dye to mix with the fluid. This test may be done when the doctor suspects a tumor in the spinal cord
WHAT IS THE TREATMENT FOR BRAIN TUMORS?
Treatment for a brain tumor depends on a number of factors. Among these are the type, location, and size of the tumor, as well as the patient’s age and general health. Treatment methods and schedules often vary for children and adults. A treatment plan is developed to fit each patient’s needs.
The patient’s doctor may want to discuss the case with other doctors who treat brain tumors. Also, the patient may want to talk with the doctor about taking part in a research study of new treatment methods. Such studies are called clinical trials.
Many patients want to learn all they can about their disease and their treatment choices so they can take an active part in decisions about their medical care. A person with a brain tumor will have many questions, and the doctor is the best person to answer them. Most patients want to know what kind of tumor they have, how it can be treated, how effective the treatment is likely to be, and how much it is likely to cost.
Many people find it helpful to make a list of their questions before they see the doctor. Taking notes can make it easier to remember what the doctor says. Some patients also find that it helps to have a family member or friend with them when they talk with the doctor,either to take part in the discussion or just to listen.
Patients and their families have a lot to learn about brain tumors and their treatment. They should not feel that they need to understand everything the first time they hear it. They will have other chances to ask the doctor to explain things that are not clear.
Treatment Methods
Brain tumors are treated with surgery, radiation therapy, and chemotherapy. Depending on the patient’s needs, several methods may be used. The patient may be referred to doctors who specialize in different kinds of treatment and work together as a team. This medical team often includes a neurosurgeon, a medical oncologist, a radiation oncologist, a nurse, a dietitian, and a social worker. The patient also might work with a physical therapist, an occupational therapist, and a speech therapist.
Before treatment begins, most patients are given steroids, which are drugs that relieve swelling (edema). They also may be given anticonvulsant medicine to prevent or control seizures. If hydrocephalus (a condition which results in fluid accumulation around the brain) is present, the patient may need a shunt to drain the cerebrospinal fluid. A shunt is a long, thin tube placed in a ventricle of the brain and then threaded under the skin to another part of the body, usually the abdomen. It works like a drainpipe: excess fluid is carried away from the brain and is absorbed in the abdomen. (In some cases, the fluid is drained into the heart).
Surgery is the usual treatment for most brain tumors. To remove a brain tumor, a neurosurgeon makes an opening in the skull. This operation is called a craniotomy.
Whenever possible, the surgeon attempts to remove the entire tumor. However, if the tumor cannot be completely removed without damaging vital brain tissue, the doctor removes as much of the tumor as possible. Partial removal helps to relieve symptoms by reducing pressure on the brain and reduces the amount of tumor to be treated by radiation therapy or chemotherapy.
Some tumors cannot be removed. In such cases, the doctor may do only a biopsy. A small piece of the tumor is removed so that a pathologist can examine it under a microscope to determine the type of cells it contains. This helps the doctor decide which treatment to use.
Sometimes, a biopsy is done with a needle. Doctors use a special head frame (like a halo) and CT scans or MRI to pinpoint the exact location of the tumor. The surgeon makes a small hole in the skull and then guides a needle to the tumor. (Using this technique to do a biopsy or for treatment is called stereotaxis).
Radiation therapy (also called radiotherapy) is the use of high-powered rays to damage cancer cells and stop them from growing. It is often used to destroy tumor tissue that cannot be removed with surgery or to kill cancer cells that may remain after surgery. Radiation therapy is also used when surgery is not possible.
Radiation therapy may be given in two ways. External radiation comes from a large machine. Generally, external radiation treatments are given 5 days a week for several weeks. The treatment schedule depends on the type and size of the tumor and the age of the patient. Giving the total dose of radiation over an extended period helps to protect healthy tissue in the area of the tumor.
Radiation can also come from radioactive materials placed directly in the tumor (implant radiation therapy). Depending on the material used, the implant may be left in the brain for a short time or permanently. Implants lose a little radioactivity each day. The patient stays in the hospital for several days while the radiation is most active.
External radiation may be directed just to the tumor and the tissue close to it or, less often, to the entire brain (sometimes the radiation is also directed to the spinal cord). When the whole brain is treated, the patient often receives an extra dose of radiation to the area of the tumor. This boost can come from external radiation or from an implant.
Stereotactic radiosurgery is another way to treat brain tumors. Treatment is given in just one session; high- energy rays are aimed at the tumor from many angles. In this way, a high dose of radiation reaches the tumor without damaging other brain tissue. (This use of radiation therapy is sometimes called Gamma Knife® Surgery).
Chemotherapy is the use of drugs to kill cancer cells. The doctor may use just one drug or a combination, usually giving the drugs by mouth or by injection into a blood vessel or muscle. Intrathecal chemotherapy involves injecting the drugs into the cerebrospinal fluid.
Chemotherapy is usually given in cycles: a treatment period followed by a recovery period, then another treatment period, and so on. Patients often do not need to stay in the hospital for treatment. Most drugs can be given in the doctor’s office or the outpatient clinic of a hospital. However, depending on the drugs used, the way they are given, and the patient’s general health, a short hospital stay may be necessary.
Clinical Trials
Researchers are looking for treatment methods that are more effective against brain tumors and have fewer side effects. When laboratory research shows that a new method has promise, doctors use it to treat cancer patients in clinical trials. These trials are designed to answer scientific questions and to find out whether the new approach is both safe and effective. Patients who take part in clinical trials make an important contribution to medical science and may have the first chance to benefit from improved treatment methods.
Many clinical trials of new treatments for brain tumors are under way. Doctors are studying new types and schedules of radiation therapy, new anticancer drugs, new drug combinations, and combinations of chemotherapy and radiation.
Scientists are trying to increase the effectiveness of radiation therapy by giving treatments twice a day instead of once. Also, they are studying drugs called radiosensitizers. These drugs make the cancer cells more sensitive to radiation. Another method under study is hyperthermia , in which the tumor is heated to increase the effect of radiation therapy.
Many drugs cannot reach the brain cells because of the blood- brain barrier, a network of blood vessels and cells that filters blood going to the brain. Researchers continue to look for new drugs that will pass through the blood-brain barrier. Studies are under way using different techniques to temporarily disrupt the barrier so that drugs can reach the tumor.
In other studies, scientists are exploring new ways to give the drugs. Drugs may be injected into an artery leading to the brain or may be put directly into the ventricles. Doctors also are studying the effectiveness of placing tiny wafers containing anticancer drugs directly into the tumor (the wafers dissolve over time).
Researchers are also testing the use of very high doses of anticancer drugs. Because these higher doses may damage healthy bone marrow, doctors combine this treatment with bone marrow transplantation to replace the marrow that has been destroyed.
Biological therapy is a new way of treating brain tumors that is currently under study. This type of treatment is an attempt to improve the way the body’s immune system fights disease.
Patients interested in taking part in a clinical trials should discuss this option with their doctor. They may want to read “What Are Clinical Trials All About?”, a National Cancer Institute (NCI) booklet that explains some of the possible benefits and risks of treatment studies.
One way to learn about clinical trials is through PDQ, a computerized resource of cancer treatment information. Developed by NCI, PDQ contains an up-to-date list of trials in progress all over the country. Doctors can use a personal computer or the services of a medical library to get PDQ information. The Cancer Information Service, at 1-800-4-CANCER, is another source of PDQ information for doctors, patients, and the public.
WHAT ARE THE SIDE EFFECTS OF TREATMENT FOR BRAIN CANCER?
Cancer treatment often causes side effects. These side effects occur because treatment to destroy cancer cells damages some healthy cells as well.
The side effects of cancer treatment vary. They depend on the type of treatment used and on the area being treated. Also, each person reacts differently. Attempts are made to plan the patient’s therapy to keep side effects to a minimum. Patients are very carefully watched so that any problems which occur can be addressed.
A craniotomy is a major operation. The surgery may damage normal brain tissue, and edema may occur. Weakness, coordination problems, personality changes, and difficulty in speaking and thinking can result. Patients can also have seizures. In fact, for a short time after surgery, symptoms may be worse than before. Most of the side effects of surgery lessen or disappear with time.
Most of the side effects of radiation therapy go away soon after treatment is over. However, some side effects may occur or persist long after treatment is completed.
Some patients have nausea for several hours after treatment. Patients receiving radiation therapy may become very tired as treatment continues. Resting is important, but doctors usually advise their patients to try to stay reasonably active. Radiation therapy to the scalp causes most patients to lose their hair. When it grows back, the new hair is sometimes softer and may be a slightly different color. In some cases, hair loss is permanent.
Skin reactions in the treated area are common. The scalp and ears may be red, itchy, or dark. These areas may look and feel sunburned. The treated area should be exposed to the air as much as possible but should be protected from the sun. Patients should not wear anything on the head that might cause irritation. Good skin care is important at this time. The doctor may suggest certain kinds of soap or ointment, and patients should not use any other lotions or creams on the scalp without the doctor’s advice.
Sometimes, brain cells killed by radiation form a mass in the brain. The mass may look like a tumor and may cause similar symptoms, such as headaches, memory loss, or seizures. Doctors may suggest surgery or steroids to relieve these problems. About 4 to 8 weeks after radiation therapy, patients may become quite sleepy or lose their appetite. These symptoms may last several weeks, but they usually go away on their own. Still, patients should notify the doctor if they occur.
Children who have had radiation therapy for a brain tumor may have learning problems or partial loss of eyesight. If the pituitary gland is damaged, children may not grow or develop normally.
The side effects of chemotherapy depend on the drugs that are given. In general, anticancer drugs affect rapidly growing cells, such as blood cells that fight infection, cells that line the digestive tract, and cells in the hair follicles. As a result, patients may have a lowered resistance to infection, loss of appetite, nausea, vomiting, or mouth sores. Patients also may have less energy and lose their hair. These side effects usually go away gradually after treatment stops.
Some anticancer drugs can cause infertility. Women taking certain anticancer drugs may have symptoms of menopause (hot flashes and vaginal dryness; periods may be irregular or stop). Some drugs used to treat children and teenagers may affect their ability to have children later in life.
Certain drugs used in the treatment of brain tumors can cause kidney damage. Patients are given large amounts of fluid while taking these drugs. Patients also may have tingling in the fingers, ringing in the ears, or difficulty hearing. These problems may not clear up after treatment stops.
Treatment with steroids to reduce swelling in the brain can cause increased appetite and weight gain. Swelling of the face and feet is common. Steroids can also cause restlessness, mood swings, burning indigestion, and acne . Patients should not stop using steroids or change their dose without consulting the doctor, however. The use of steroids must be stopped gradually to allow the body time to adjust.
Loss of appetite can be a problem for patients during therapy. People may not feel hungry when they are uncomfortable or tired. Some of the common side effects of cancer treatment, such as nausea and vomiting, can also make it hard to eat. Yet, good nutrition is important because patients who eat well generally feel better and have more energy. In addition, they may be better able to withstand the side effects of treatment. Eating well means getting enough calories and protein to help prevent weight loss, regain strength, and rebuild normal tissues. Many patients find that eating several small meals and snacks during the day works better than trying to have three large meals.
Patients being treated for a brain tumor may develop a blood clot and inflammation in a vein, most often in the leg. This is called thrombophlebitis. A patient who notices swelling in the leg, leg pain, or redness in the leg should notify the doctor right away.
Doctors, nurses, and dietitians can explain the side effects of cancer treatment and can suggest ways to deal with them.
WHAT IS REHABILITATION AFTER BRAIN CANCER TREATMENT?
Rehabilitation is a very important part of the treatment plan. The goals of rehabilitation depend on the patient’s needs and how the tumor has affected his or her daily activities. The medical team makes every effort to help patients return to their normal activities as soon as possible.
Patients and their families may need to work with an occupational therapist to overcome any difficulty in activities of daily living, such as eating, dressing, bathing, and using the toilet. If an arm or leg is weak or paralyzed, or if a patient has problems with balance, physical therapy may be necessary. Speech therapy may be helpful for individuals having trouble speaking or expressing their thoughts. Speech therapists also work with patients who are having difficulty swallowing.
If special arrangements are necessary for school-age children, they should be made as soon as possible. Sometimes, children have tutors in the hospital or after they go home from the hospital. Children who have problems learning or remembering what they learn may need tutors or special classes when they return to school.
WHAT HAPPENS AFTER TREATMENT FOR BRAIN CANCER?
Regular follow-up is very important after treatment for a brain tumor. The doctor will want to check closely to be sure that the tumor has not returned. Check-ups usually include general physical and neurologic exams. From time to time, the patient will have CT scans or MRI.
Patients who receive radiation therapy to large areas of the brain or certain anticancer drugs may have an increased risk of developing leukemia or a second tumor at a later time. Also, radiation that affects the eyes may lead to the development of cataracts . Patients should carefully follow their doctor’s advice on health care and checkups. If any unusual health problem occurs, they should report it to the doctor as soon as it appears.
The diagnosis of a brain tumor can change the lives of patients and the people who care about them. These changes can be hard to handle. Patients and their families may have many different and sometimes confusing emotions.
At times, patients and those close to them may feel frightened, angry, or depressed. These are normal reactions when people face a serious health problem. Most patients, including children and teenagers, find it helps to share their thoughts and feelings with loved ones. Sharing can help everyone feel more at ease and can open the way for others to show their concern and offer their support.
Worries about tests, treatments, hospital stays, rehabilitation, and medical bills are common. Parents may worry about whether their children will be able to take part in normal school or social activities. Doctors, nurses, social workers, and other members of the health care team may be able to calm fears and ease confusion. They also can provide information and suggest helpful resources.
Patients and their families are naturally concerned about what the future holds. Sometimes, they use statistics to try to figure out whether the patient will be cured or how long he or she will live. It is important to remember, however, that statistics are averages based on large numbers of patients. They can’t be used to predict what will happen to a certain patient because no two cancer patients are alike. The doctor who takes care of the patient and knows that person’s medical history is in the best position to discuss the patient’s outlook (prognosis).
People should feel free to ask the doctor about their prognosis, but it is important to keep in mind that not even the doctor can tell exactly what will happen. When doctors talk about recovering from a brain tumor, they may use the term remission rather than cure. Even though many people recover completely, doctors use this term because a brain tumor can recur.
WHAT SUPPORT IS AVAILABLE TO CANCER PATIENTS?
Living with a serious disease is not easy. Everyone involved faces may problems and challenges. Finding the strength to cope with these difficulties is easier when people have helpful information and support services.
The doctor can explain the disease and give advice about treatment, going back to work or school, or other activities. If patients want to discuss concerns about the future, family relationships, and finances, it also may help to talk with a nurse, social worker, counselor, or a member of the clergy.
Friends and relatives who have had personal experience with cancer can be very supportive. Also, it helps many patients to meet and talk with other people who are facing problems like theirs. Cancer patients often get together in self-help and support groups, where they can share what they have learned about cancer and its treatment and about coping with the disease. In addition to groups for adults with cancer, special support groups for children or teens with cancer or for parents whose children have cancer are available in many cities. It is important to keep in mind, however, that each patient is different. Treatments and ways of dealing with cancer that work for one person may not be right for another, even if they both have the same kind of cancer. It is a good idea to discuss the advice of friends and family members with the doctor.
Often, a social worker at the hospital or clinic can suggest local and national groups that will help with rehabilitation, emotional support, financial aid, transportation, or home care. The American Cancer Society is one such group. This nonprofit organization has many services for patients and their families.
The American Brain Tumor Association is another organization that can help patients find support groups in local areas.
Candlelighters Childhood Cancer Foundation sponsors support groups for parents of children with cancer. In some cities, the Foundation has special groups for children or teens with cancer, as well.
Information about other programs and services for cancer patients and their families is available through the Cancer Information Service. The toll-free number is 1-800-4-CANCER.
BRAIN TUMORS AT A GLANCE
* Brain tumors can be either malignant or benign
* The causes of brain tumors are not known
* Brain tumors can occur at any age
* Primary brain tumors initially form in the brain tissue
* Secondary brain tumors are cancers that have spread to the brain tissue from tissue elsewhere in the body
* The symptoms of brain tumors depend on their size and their location in the brain
* Brain tumors are diagnosed by the doctor based on the results of a medical history and physical examination and results of a variety of specialized tests of the brain and nervous system
* Treatment of a brain tumor depends on the type, location, and size of the tumor, as well as the age and health of the patient
Further Reading: http://www.elekta.com/gammaknife
The three modalities in current use for the treatment of cancer are surgery, radiotherapy and chemotherapy. Enough is known about the therapeutic management of cancer to be able to decide in advance, in each case, which of the three modalities to choose as the main line of treatment, either in isolation or in association with one or both of the other two modalities.
Radiotherapy
After surgery, radiotherapy is the most effective treatment in the management and cure of cancer. It plays a significantly greater role than Chemotherapy. Approximately 70% of patients who come to radiotherapy departments receive treatment with curative intent, either by radiotherapy alone or in conjunction with surgery and chemotherapy. Of these, approximately 50% are cured.Those treated with palliative intent will have had their quality of life improved by their radiotherapy. As a result of new imaging and computer technology, the outcomes for radiotherapy have steadily improved over the last 20 years. Further developments offer the prospect of up to 10% improvement in cure rates for patients having radical treatment.1
Surgery
Generally, surgery on its own can only be regarded as the treatment choice if the solitary tumor is relatively small, mobile, readily accessible and with no evidence of spread to local lymph nodes or elsewhere, so that removal of every cancer cell is assured.
Chemotherapy
Chemotherapy is the simultaneous administration of multiple drugs, which results in the summation of their destructive power on the tumor,but no similar increase in the side effects. This has made chemotherapy the treatment of choice in some leukemias, certain types of Hodgkin’s and Non-Hodgkin’s Disease, as well as following removal of testicular tumor (remarkable for its sensitivity to damage by chemotherapy).
1 Einhorn, J., Frôdin, J.E. et al. (1997) Radiotherapy for Cancer, Vol. 1, Acta Oncologica, 36, suppl. 6.
Cancer is a group of many related diseases. All forms of cancer involve out-of-control growth and spread of abnormal cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide more rapidly until the person becomes an adult. After that, normal cells of most tissues divide only to replace worn-out or dying cells and to repair injuries. Cancer cells, however, continue to grow and divide, and can spread to other parts of the body. These cells accumulate and form tumors (lumps) that may compress, invade, and destroy normal tissue. If cells break away from such a tumor, they can travel through the blood stream or the lymph system to other areas of the body. There, they may settle and form ‘colony’ tumors. In their new location, the cancer cells continue growing. The spread of a tumor to a new site is called metastasis. When cancer spreads, though,it is still named after the part of the body where it started. For example, if prostate cancer spreads to the bones, it is still prostate cancer, and if breast cancer spreads to the lungs it is still called breast cancer. Leukemia, a form of cancer, does not usually form a tumor. Instead, these cancer cells involve the blood and blood-forming organs (bone marrow, lymphatic system, and spleen), and circulate through other tissues where they can accumulate.
It is important to realize that not all tumors are cancerous. Benign (non-cancerous) tumors do not metastasise and, with few exceptions, are not life-threatening. Cancer is classified by the part of the body in which it began,and by its appearance under a microscope. Different types of cancer vary in their rates of growth, patterns of spread, and responses to different types of treatment. That’s why people with cancer need treatment that is aimed at their specific form of the disease.
X-ray – Electromagnetic radiation used to diagnose (low energy) and treat (high energy) disease.
X-ray Volume Imaging (XVI) – X-ray Volume Imaging (XVI) technology enables visualization of soft tissue detail in any area of the body.
Volumetric Modulated Arc Therapy (VMAT) – Volumetric Modulated Arc Therapy (VMAT) is a new intensity-modulated radiation therapy (IMRT) treatment technique that provides a simultaneous control of the linear accelerator gantry position and speed, the leaves and angle of the multileaf collimator and dose rate. This enables highly conformal cancer treatments, as well as optimal sparing of the healthy tissue around the target. In addition, VMAT significantly reduces patient treatment times, leading to greater patient comfort and stillness for a more efficient and precise treatment.
Teletherapy – Radiation delivered at a distance. cf. Brachytherapy where radiation is delivered locally by a source in contact with the patient. Cobalt 60 and linear accelerators are teletherapy machines.
Therapeutic – Curative
Tomography – Any of several techniques for making detailed x-rays of a predetermined plane section of a solid object.
Total Body Irradiation (TBI) – A radiotherapy treatment performed for some leukemia conditions. May involve the removal and replacement of the patient’s bone marrow after extra-corporeal irradiation.
Treatment planning – The act of producing a treatment plan. Can be performed by hand or by computer. Computers can produce plans from data derived from CT and MRI machines allowing the generation of 2-D, 2.5-D and 3-D plans.
Treatment volume – The three dimensional region within a body to which the prescribed dose is delivered.
Trigeminal nerve – The trigeminal nerve functions both as the chief nerve of sensation for the face and the motor nerve controlling the muscles of mastication (chewing).
Tumor – Mass of tissue formed by a new growth of cells, can be either benign or malignant.
